The 4.88 and 5.38 gear sets only came in the F450 and F550 series trucks which have higher GVWR and need the lower gears to move the greater mass. F250 came with 3.73 axle ratio. To check your axle ratio look in the glovebox for a sticker - the ratio should be listed on there. Check out
Yukon Gear & Axle and you'll be able to find axle ratios. Best thing is to contact them, or another local place that installs gears to know what you'll be able to put in your axles. I'm guessing a 4.30 or 4.56 ratio may be the highest you can go in the F250. If you have 4.1's already you won't notice much gain with a 4.56 setup, but it'll still help.