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Depends on the year and the wheel backspace measurement.
On an '06, you can go to 285/70-17 with the stock 6" backspace. If you go to 315's, it will rub at full lock, but if you go to a 4.5" backspace, they will clear.
Older trucks ('03 and earlier, I think) had a 4.5" backspace as stock. Not sure what will or will not fit them.
I've got an 04, F250, short bed, 4x4, 5.4L, and I run 315/75/R16 and they only rub at full over when turning. BFG A/T and I got 80,000 miles out of them.